BIOSCIENCE TOOLS
 
 Ph: 877-853-9755
 Fax: 866-533-7490
 Email info@biosciencetools.com

 
Test substance application Dose-response acquisition Ca imaging Ca imaging
Time lapsed imaging Anaerobic conditions and hypoxia Mini- Incubators Micro Incubators for Coverslips
temperature controllers miniature pumps Objective heater Cooling stages
Patch-Clamp DNA amplification zebra-fish imaging AFM imaging


Contact Us
BIOSCIENCE TOOLS
Ph: 877-853-9755,
Fax: 866-533-7490
Email info@biosciencetools.com
CONTROLLED FLOW PERFUSION SYSTEM This is a perfusion system for precise linear control of solution flow rate over the range from 0.34 l/min to 22 ml/min. Precision design and miniature size minimize pulsations to provide smooth perfusion. Designed for stable solution flow or substance application during imaging, calcium and other ions measurement, recording, biochemical assays or small organs and animals perfusion. Used with small chambers in lab-on-chip setups, imaging and recording workstations, and to perfuse small organs and animals in micro-perfusion setups. Ten-turn dials (or analog inputs) allow to calibrate each channel independently and to apply one or multiple substances by switching channels manually or through data acquisition and imaging software. Manual single units can be also used as a source of vacuum to remove solution from your sample chambers during perfusion because the units are so small that they can be mounted next to your samples.. You can accurately mix different solutions or generate dose-response curves using only two solutions: control and concentrated test compound. You can even generate concentration gradients in time to simulate substance distribution in time, and concentration gradients throughout the space of small chambers to assess chemotaxis, for example. Each channel can be controlled manually, by analog signal, TTL or through RS232 connection for fully automated setups controlled through our or third party software packages, imaging for example (optional USB adapters are also available). Multipple units can be attached to each other to form a multi-channel system. The size of the 2-channel unit is 4x2.5x1.85 in (separate from the controller). The controller can read analog signals (temperature, for example) to automate environment control. The controllers can be also used with our optional disposable flow meters and high power switch to setup an automated system to measure and dispense solutions using high flow rate pumps in the range from 70ml/min to 25 l/min, with precision of 200l. PERFUSION CHAMBER-INSERT for PETRI DISH - PDI Cells cultured in 35 mm Petri dishes are a popular research tool used in numerous applications, including patch clamping and intracellular ion probe imaging. However, true perfusion (continuous inflow and outflow) of solutions can be difficult to configure. Drug delivery without an outflow requires a Picospritzer-type microinjector, but ultimately results in contamination of the entire dish after only a few applications. This forces scientists to plate cells on coverslips for placement into specially designed perfusion chambers. However, such transfer is a time consuming process which introduces the potential for contamination plus additional expense. The PDI chamber was designed by scientists after several years of patch clamp research combined with external perfusion of single cells cultured in Petri dishes. The chamber has separate openings for solution inflow and outflow that dampen the fluctuations of the liquid level in the working compartment and prevents bubbles from entering the chamber. An adjustable metal suction tube (included) helps to control the level of liquid in the dish. The chamber was designed for use with automated perfusion systems and can accommodate commercially available Teflon manifolds (optional). Choose from chambers to fit Corning, Falcon, or Nunc 35 mm dishes. The chamber also fits to thin coverslip bottom dishes and could be a perfect companion for those who want to change solutions during fluorescence experiments. Small Volume Perfusion System - SVDS1 The majority of available perfusion systems have long lines of tubing, which have to be filled before conducting experiments. However, sometimes applied substances are available only in limited quantities or are extremely expensive, prohibiting the usage of conventional perfusion systems. To minimize the waste of applied substances, we have designed the 8-channel small volume delivery system. The system utilizes small plastic tubes with conical bottom and thin polyimide tubing to connect to a maltibarrel micropipette or a micromanifold. It could be used with as little as 100 µl volumes of perfusate. CONTROLLED ENVIRONMENT CLOSED IMAGING CHAMBER Could be used with four standard 25 mm glass coverslips to form optical quality surfaces on the bottom and on the top of the media and above the gas mixture to control the atmosphere (pH) and to prevent condensation. Easy to assemble. Includes stainless suction tubing for continuous media exchange and luer connector for gas mixture input (from a cylinder with CO2/O2, for example). Easily converts to sealed or open chamber. The chamber has separate compartments for solution inflow and outflow to provide smooth perfusion and to prevent bubbles from coming into the working area. Consider adding a miniature perfusion system. Fits into heating stages of our temperature controllers. CONTROLLED FLOW PERFUSION SYSTEM This is a perfusion system for precise linear control of solution flow rate over the range from 0.34 l/min to 22 ml/min. Precision design and miniature size minimize pulsations to provide smooth perfusion. Designed for stable solution flow or substance application during imaging, recording, calcium and other ions measurement, biochemical assays or small organs and animals perfusion. Used with small chambers in lab-on-chip setups, imaging and recording workstations, and to perfuse small organs and animals in micro-perfusion setups. Ten-turn dials (or analog inputs) allow to calibrate each channel independently and to apply one or multiple substances by switching channels manually or through data acquisition and imaging software. You can accurately mix different solutions or generate dose-response curves using only two solutions: control and concentrated test compound. You can even generate concentration gradients in time to simulate substance distribution in time, and concentration gradients throughout the space of small chambers to assess chemotaxis, for example. Each channel can be controlled manually, by analog signal, TTL or through RS232 connection for fully automated setups controlled through third party software packages, imaging for example (optional USB adapters are also available). Multiple systems could be attached to each other to form a multi-channel system. The size of the 2-channel system is 4x2.5x1.85 in (separate from the controller). Can read up to eight analog signals (temperature, for example) to automate environment control. Can be used with our optional disposable flow meters and high power switch to setup an automated system to measure and dispense solutions using high flow rate pumps in the range from 70ml/min to 25 l/min, with precision of 200l. CONTROLLED FLOW PERFUSION SYSTEM This is a perfusion system for precise linear control of solution flow rate over the range from 0.34 l/min to 22 ml/min. Precision design and miniature size minimize pulsations to provide smooth perfusion. Designed for stable solution flow or substance application during imaging, recording, calcium and other ions measurement, biochemical assays or small organs and animals perfusion. Used with small chambers in lab-on-chip setups, imaging and recording workstations, and to perfuse small organs and animals in micro-perfusion setups. Ten-turn dials (or analog inputs) allow to calibrate each channel independently and to apply one or multiple substances by switching channels manually or through data acquisition and imaging software. You can accurately mix different solutions or generate dose-response curves using only two solutions: control and concentrated test compound. You can even generate concentration gradients in time to simulate substance distribution in time, and concentration gradients throughout the space of small chambers to assess chemotaxis, for example. Each channel can be controlled manually, by analog signal, TTL or through RS232 connection for fully automated setups controlled through third party software packages, imaging for example (optional USB adapters are also available). Multiple systems could be attached to each other to form a multi-channel system. The size of the 2-channel system is 4x2.5x1.85 in (separate from the controller). Can read up to eight analog signals (temperature, for example) to automate environment control. Can be used with our optional disposable flow meters and high power switch to setup an automated system to measure and dispense solutions using high flow rate pumps in the range from 70ml/min to 25 l/min, with precision of 200l. Perfusion Systems Flow Control Temperature Control Miniature Holders Miniature Manifolds Local Perfusion Small Volume Delivery System Perfusion Chambers for replaceable coverslip Ultra-Thin Imaging Chambers Closed Controlled Environment Chambers & Mini-Incubators Gradient Chambers Uniform Heating Slide Heaters Micro-Perfusion Automated Workstations Multi-Channel Systems Chambers, Thin profile, Heated, Perfusion, for AFM and Water Immersion Accessories Low Profile Heated Chambers Data Acquisition Computer-based Data Acquisition Electrophysiology Accessories Accessories Electrophysiology Workstations Patch Clamp Experimental Rigs & Faraday Cages Faraday Cages Flash Photolysis System The Xenon Arc Flash Photolysis System Fluorescence Workstations Monochromator Based Systems Glass Bottom Petri Dishes Accessories Sterile Dishes Gradient Chambers Accessories Imaging Chambers Imaging Slides, Heating & Accessories Temperature Control & Holders Imaging Systems Color Imaging Systems Enhanced Imaging Systems Imaging, High Resolution Chambers Accessories Chambers with Transparent Uniform Heaters Heated Chambers Open Chambers Thin Sealed Chambers Injection and Micromanipulation Workstations Accessories Inverted Phase Contrast and DIC microscope stations Stereo Microscope Stations Injectors Accessories Complete Injection Systems Microinjectors Magnetic & Screw-Type Holders, Miniature Accessories Holders Manipulators, Accessories Accessories for UM series Headstage Adapters and Electrode Holders Magnetic Stands, Clamps and Joints Manipulators, Coarse One-Dimensional Three-Dimensional Two-Dimensional Manipulators, Fine Mechanical Joystic Type One-Dimensional Three-Dimensional Two-Dimensional Manipulators, High Resolution Motorized Micromanipulators Manipulators, Hydraulic Single-Axis Three-axis Manipulators, Microscope Adapters Isolation Systems Leica Microscopes Nikon Microscopes Olympus Microscopes Zeiss Microscopes Manipulators, Miniature Compact Accessories Installation One-Dimensional Three-Dimensional Manipulators, Motor-driven and Piezo-Injectors Motor Drive Piezoelectric Manipulators, Multiple Pipettes Holders Manipulators Membrane capacitance measurements Optopatch Amplifier Micropipette Pullers, Microforges and Grinders Capillaries for Injection Grinders Microforges Multibarrel Capillaries Patch Clamp Glass Capillaries Pullers Microscope Accessories Eyepieces Heads Miscellaneous Photo/Video Adapters Reticles Upgrade Packages Microscope/Manipulators Isolation/Translation Tables Isolation Table Microscope Translation Stages X-Y Base Microscopes, Fluorescence Filters and Objectives Fluorescence Microscopes Hybridization and Incubation on Slides Live Imaging Chambers Microscopes, Inverted Biological Inverted Microscopes Inverted Material Research Microscopes Microscopes, Laboratory Fluorescence Microscopes Laboratory Microscopes Material Research Microscopes Objectives Microscopes, Stereo Accessories Stereo Microscopes Optical Monochromators Monochromator Systems Patch Clamp Amplifiers Data Acquisition Interfaces Patch Clamp Amplifier Perfusion Accessories, Micro-Manifolds and Tubing micro-Manifolds Miscellaneous Perfusion Pumps Small Volume Delivery Systems Tubing & Fitting Perfusion Chambers Controlled Environment Closed Imaging Chambers CoverSlip Chambers Oocyte chambers Petri Dish Inserts Perfusion Dish for High Resolution Imaging P-Dish Perfusion Systems, Fast and Miniature 1.5 msec response time 10-25 msec response time Accessories Pinch Valves Perfusion Systems Perfusion Systems, Flow Control Accessories Miniature Perfusion Systems Perfusion systems, Intracellular Pipette Adapter Based Perfusion Systems, Micro Perfusion Sets Accessories Micro Perfusion Sets Perfusion Systems, Ultra-fast Sub-Milisecond Solution Switch System Pressure Micro Injectors - Spritzers 1-Channel Injectors 4, 8-channel Micro Injectors - Spritzers Accessories Software Automation Software Data Acquisition Imaging Software Stimulators and Isolators Microforge for Metal Electrodes Stimulators and Isolators Stimulus Electrodes Temperature Controllers, Heating 1-Channel Controller, Low Electrical Noise 2-Channel Temperature Controller Accessories Miniature Temperature Controller Ultra Fast Temperature Change Temperature Controllers, Heating & Cooling Bipolar Heating/Cooling Controllers Two Electrode Voltage Clamp/Oocyte Amplifier Voltage Clamp Amplifier Vibration Isolation Tables Accessories Air Vibration Isolation Lab Tables CB Consulting Inc.