Pinch Valve Systems
Solenoid Valves
Pressure Switch
Small Volume Delivery
 
Valve Controllers
Pressure Controllers
Programmable Pumps
Miniature Pumps
 
Perfusion Setups
 
Petri Dish Perfusion
 

Media Exchange > Pinch-Valves System for automated perfusion

Complete 8/16-Channel Pinch Valves Automated Perfusion System with programmable timers and channel sequences for precise timing during manual operation

Specifications:

Pinch tubing O.D.:

1/8in. (1/16in. optional)

Remote control:

Wireless

Manifold:

8-channel, can be reduced down to 1-channel

Height:

up to 3ft. adjustable, for gravity driven solution flow

Solution cylinders:

60ml x8 syringes

Tubing:

100ft. polyethylene tubing, fits perfusion manifold directly;
50ft. Tygon tubing, fits provided barbed luer connectors for syringes

Fitting:

barbed luer-locks and ferrule-type to connect to solution cylinders and between Tygon & polyethylene tubing

Anti-vibration mounting:

a. 1x1 ft. stand,
b. magnetic stand,
c. M8 threaded surfaces



In the pinch valve a soft tubing is pinched closed by the valve, and opens when the channel is ON. The results are simple tubing replacement and easy system cleanup after experiments. Recommended for strong solvents and reagents, and for hard to wash/clean solutions. Designed for animal physiology and cell research applications. The valves are mounted inside a metal box to shield your system from electrical noise. The system comes with manifold that fits to perfusion chambers for cultured cells/tissue slices, Petri dish and oocytes. Includes soft Tygon, polyethylene tubing and fitting to connect to pinch tubing. Includes 60ml syringes/reservoirs.  Includes easy disconnect luer fitting for tubing and included syringes. Compatible with data acquisition and imaging systems, compatible with LabView, MatLab, pClamp, IPlab, PatchMaster, Metamorh, MetaFluor. Since valves are inside the metal box and are connected to the controller through shielded cables, there is no electrical noise during switching.

The included unique flexible stand provides vibration-free operation and includes both a stand and a small magnetic base. The magnetic base does not take a lot of space from your set-up, but allows to position perfusion solutions near your sample. The post consists of 0.5 in. O.D., 1 foot long aluminum parts and can be extended to 3 feet high. An 1.5 in. flowerette head screw will fix the syringes on the post, making a traditional syringe holder. Comes with 60ml syringes, stop-cocks, and fitting. The holder can be also mounted on threaded M8 surfaces. Sample publications.

Complete 16-Channel Pinch Valves Perfusion System

To form a 16-channel setup, this system includes two sets of the above parts, included with the 8-channel system, which can be operated by the same 16-channel controller.

16-channel valve controller

Both system come with a 16-channel controller. The controller opens valves through
  • manual buttons
  • wireless remote control
  • optically isolated digital or TTL signals generated by a computer or other equipment
  • analog signal
  • RS232 port (or USB connection) for software control
The controller can operate in AUTO Memory mode, to program timers and channels sequences for precise timing during manual operation;

INHIBIT mode with manual and external controls allows you to switch all channels OFF at once, if required. 

The controller has an option for valves control by Binary Encoding using only 2-4 digital inputs, in case if a limited number of digital outputs are available in your system. The RS232 port allows automation of solution switching and integration with data acquisition and imaging systems.

ANALOG output can be configured to monitor channel switching during manual operation.

SET output is used to switch an outflow unit ON automatically every time perfusion is ON.

RS232 port allows software control by any imaging or data acquisition setup. Can be upgraded to USB/RS232 adapter.

Specifications (controller):

Channels:

16

Controls:

optically isolated digital signals and TTL, Analog input, RS232 software command

Manual Overdrive:

Manual touch-pad switches, override electronical inputs

Remote control:

Wireless

Auto Memory:

To program timers and channels sequences for precise timing during manual operation

Code mode:

Use only 4 TTL inputs to encode all channels

Close mode:

Inhibits all outputs to the valves, manual and electronical inputs

Analog and SET outputs:

To switch outflow units CFPS-1U and for telegraph output

Custom modifications:

Additional features can be added or modified on request

Dimensions:

5 x 12 x 9 in.

Power:

120/240 VAC



Click on catalog numbers below to purchase online.

Download PDF manual.

Download PDF catalog.

Bioscience Tools
ph: 877-853-9755, fax: 866-533-7490
email: info@biosciencetools.com

PRICES AND OPTIONS

PS-8H

$2,995

 

Complete 8-Channel Pinch Valves Perfusion System. Includes programmable 16-channel controller, pinch valves, SH-1A syringe holder, manifold, tubing and fitting.

PS-V8

$845

Additional pinch valves, set of 8, mounted inside an aluminum box to use with perfusion systems. For use with PC-16 controller.

silicon-8

$195

Silicone soft pinch valve tubing 1/8 in. O.D., 100 feet

PS-S8

$95

Replacement 60ml syringes (containers) for perfusion systems, set of x8

PS-16H

$4,395

 

Complete 16-Channel Pinch Valves Perfusion System. Includes programmable 16-channel controller, pinch valves, SH-1A syringe holders, manifold, tubing and fitting.

Sample publications:
45 Sites of Circadian Clock Neuron Plasticity Mediate Sensory Integration and Entrainment. 2021;
44 A compact microscope for voltage imaging. Journal of Optics, Volume 24, Number 5 2022;
43 Conformational Changes in the 5-HT3A Receptor Extracellular Domain Measured by Voltage Clamp Fluorometry. Molecular Pharmacology October 3, 2019;
42 Synchronized Retrovirus Fusion in Cells Expressing Alternative Receptor Isoforms Releases the Viral Core into Distinct Sub-cellular Compartments PLoS Pathogens, Volume 8, Number 5, 2012;
41 Cotransporter-mediated water transport underlying cerebrospinal fluid formation Nature Communicationsvolume 9, Article number: 2167 (2018);
40 A novel inwardly rectifying K+ channel, Kir2.5, is upregulated under chronic cold stress in fish cardiac myocytes. Journal of Experimental Biology 2008 211: 2162-2171;
39 Full mutational mapping of titratable residues helps to identify proton-sensors involved in the control of channel gating in the Gloeobacter violaceus pentameric ligand-gated ion channel. PLOS Biology December 27, 2017;
38 Optical Quantification of Intracellular pH in Drosophila melanogaster Malpighian Tubule Epithelia with a Fluorescent Genetically-encoded pH Indicator. J. Vis. Exp. (126), e55698, doi:10.3791/55698 (2017);
37 Fusion of Mature HIV-1 Particles Leads to Complete Release of a Gag-GFP-Based Content Marker and Raises the Intraviral pH. PLoS ONE Volume 8, Number 8 2013;
36 Exocytotic release of ATP by preBötzinger Complex astrocytes contributes to the hypoxic ventilatory response via a calcium-dependent P2Y1 receptor mechanism;
35 Connectivity, Organization, and Network Coordination of the Drosophila Central Circadian Clock;
34 EFFECT OF ECONAZOLE AND BENZYDAMINE ON SENSORY NEURONS IN CULTURE. JPP No 6/2016 article 06;
33 Independent role for presynaptic FMRP revealed by an FMR1 missense mutation associated with intellectual disability and seizures. PNAS vol. 112 no. 4, 949–956;
32 Optogenetic Control of Gene Expression in Drosophila. PLOS one, September 18, 2015;
31 Spatiotemporal Coding of Individual Chemicals by the Gustatory System. The Journal of Neuroscience, 2 September 2015, 35(35): 12309-12321;
30 Evaluating the Functionality of Conjunctiva Using a Rabbit Dry Eye Model. Journal of Ophthalmology Volume 2016 (2016);
29 Visualization of retrovirus uptake and delivery into acidic endosomes. Biochemical Journal Mar 15, 2011, 434 (3) 559-569;
28 Basolateral and central amygdala differentially recruit and maintain dorsolateral striatumdependent cocaine-seeking habits. NATURE COMMUNICATIONS 14 Dec 2015;
27. Human sensory neurons: membrane properties and sensitization by inflamatory mediators. PAIN 155 (2014) 1861-1870;
26. Size-Dependent Cellular Uptake and Expulsion of Single-Walled Carbon Nanotubes: Single Particle Tracking and a Generic Uptake Model for Nanoparticles. ACS Nano, 2009, 3 (1), pp 149–158;
25. Analysis of functional neuronal connectivity in the Drosophila brain. J Neurophysiol. 2012 Jul 15; 108(2): 684–696;
24, 23, 22, 21, 20, 19, 18, 17, 16, 15, 14, 13, 12, 11, 10, 6, 7, 8, 9, 1, 2, 3, 4, 5