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Media Exchange > Valve Controllers for automated perfusion and liquid delivery

Programmable 16-Channel Valve Controller PC-16

This is a computerized controller with programmable timers to deliver liquid application sequences with precise timing even during manual operation. The controller can drive any solenoid  with a wireless remote control, digital (TTL) inputs, or software commands. To make a functional system, simply add valves below. The set of eight (x8) valves are mounted in a small aluminum box which an x-blocks: solenoid valves for larger volume perfusion and pinch valves for easy maintenance. Syringe holders and tubing might be required. The 16-channel controller is included with every 8/16-channel perfusion system. Built-in 0-15PSI pressure controller-pump (PC-16P model only). Compatible with data acquisition and imaging systems: LabView, MatLab, pClamp, IPlab, PatchMaster, Metamorph, MetaFluor and others.

AUTO Memory
The controller can store up to 16-step sequence (32-steps if wash between channels is used) to activate multiple channels in programmed order or a continuous loop. This is useful for automatic switching of liquid media in sequence, including automatic "wash" between "test" solutions applications in sequence. The sequence is programmed using the touch screen of the controller.

Digital input
Optically isolated inputs for each channel. BNC connector for TTL inputs and DB-9 connector.

The controller has an options for valves control by channel encoding using only 2-4 digital inputs, in case if a limited number of digital outputs is available in your system.

Analog Input
You can also use analog signal input to switch the channels by changing the voltage (0.5V increment).

USB/RS232 Input
The RS232 port allows automation of solution switching and integration with imaging systems.

5V TTL signal output to switch inflow/outflow pump automatically.

Closes valves regardless of input.

Specifications (controller):




x2 DB-9 connectors, max 5A per channel, 12VDC standard (up to 35V)

Pressure (PC-16P model):

0-15 PSI, easy-connect fitting for 1/8in. O.D. tubing (#10-32 threaded, fits M5)


Optically isolated digital TTL, Analog input, RS232 software command

Manual Overdrive:

Manual control override electronical inputs

Remote control:


Auto Memory:

precise timers with 1ms precision; automatically performs preset channels sequences

Code mode:

Use only 4 TTL inputs to encode all channels

Close mode:

Inhibits all outputs to the valves, manual and electronical inputs

SET outputs:

To switch outflow units CFPS-1U66 or for telegraph output

Programmable timers:

1ms accuracy, stored in memory (for each channel)


5 x 13 x 9 in.


120/240 VAC internal power supply

The whole cell recording of glutamate transporter responses to glutamate applications using PC-16 valve controller based perfusion system. Provided by Dr. Kabakov, Harvard University Medical School

Sample publications.

Click on catalog numbers below to purchase online.

Required accessories: valves (see below).

Optional accessories: perfusion accessories, flow control.

Download PDF manual.

Download PDF catalog.

Bioscience Tools
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16-Channel Valve Controller



16-Channel Valve Controller with 0-15PSI pressure pump



Solenoid valves, set of 8, mounted inside an aluminum box to use with perfusion systems. For use with PC-16 controller, that can operate up to 16-valves.



Pinch valves, set of 8, mounted inside an aluminum box to use with perfusion systems. Combined with PC-16 controller, makes a basic system. The 16-channel controller can operate two 8-valve assemblies. Includes pinch tubing 1/8in. O.D., all fitting, and 8-channel manifold. Includes X-blocks to mount on standard 0.5 in. posts or syringe holders. Requires SH-1A syringe holder, and tubing (some extra fitting might be required).



8-Channel pressure manifold-switch



Small Volume Perfusion System SVDS2 with pressure switch



USB Adapter. Converts your computer USB ports into RS232 ports. Includes cables and software drivers.



Cable to connect valve controllers to imaging systems. A custom cable to fit your imaging system. Used with imaging software to control perfusion systems for automatic liquid handling and test solution applications. Specify imaging package used or define required connectors.

Sample publications:
47 TRPM8 contributes to sex dimorphism by promoting recovery of normal sensitivity in a mouse model of chronic migraine. Nature Communications, ( 2022) 13:6304;
46 A compact microscope for voltage imaging. Journal of Optics, Volume 24, Number 5, 2022;
45 Androgenic TRPM8 activity drives sexual dimorphism in a murine model of chronic migraine. Research Square October 19th, 2021;
44 Sites of Circadian Clock Neuron Plasticity Mediate Sensory Integration and Entrainment. 2021;
43 Conformational Changes in the 5-HT3A Receptor Extracellular Domain Measured by Voltage Clamp Fluorometry. Molecular Pharmacology October 3, 2019;
42 Synchronized Retrovirus Fusion in Cells Expressing Alternative Receptor Isoforms Releases the Viral Core into Distinct Sub-cellular Compartments PLoS Pathogens, Volume 8, Number 5, 2012;
41 Cotransporter-mediated water transport underlying cerebrospinal fluid formation Nature Communicationsvolume 9, Article number: 2167 (2018);
40 A novel inwardly rectifying K+ channel, Kir2.5, is upregulated under chronic cold stress in fish cardiac myocytes. Journal of Experimental Biology 2008 211: 2162-2171;
39 Full mutational mapping of titratable residues helps to identify proton-sensors involved in the control of channel gating in the Gloeobacter violaceus pentameric ligand-gated ion channel. PLOS Biology December 27, 2017;
38 Optical Quantification of Intracellular pH in Drosophila melanogaster Malpighian Tubule Epithelia with a Fluorescent Genetically-encoded pH Indicator. J. Vis. Exp. (126), e55698, doi:10.3791/55698 (2017);
37 Fusion of Mature HIV-1 Particles Leads to Complete Release of a Gag-GFP-Based Content Marker and Raises the Intraviral pH. PLoS ONE Volume 8, Number 8 2013;
36 Exocytotic release of ATP by preBötzinger Complex astrocytes contributes to the hypoxic ventilatory response via a calcium-dependent P2Y1 receptor mechanism;
35 Connectivity, Organization, and Network Coordination of the Drosophila Central Circadian Clock;
33 Independent role for presynaptic FMRP revealed by an FMR1 missense mutation associated with intellectual disability and seizures. PNAS vol. 112 no. 4, 949–956;
32 Optogenetic Control of Gene Expression in Drosophila. PLOS one, September 18, 2015;
31 Spatiotemporal Coding of Individual Chemicals by the Gustatory System. The Journal of Neuroscience, 2 September 2015, 35(35): 12309-12321;
30 Evaluating the Functionality of Conjunctiva Using a Rabbit Dry Eye Model. Journal of Ophthalmology Volume 2016 (2016);
29 Visualization of retrovirus uptake and delivery into acidic endosomes. Biochemical Journal Mar 15, 2011, 434 (3) 559-569;
28 Basolateral and central amygdala differentially recruit and maintain dorsolateral striatumdependent cocaine-seeking habits. NATURE COMMUNICATIONS 14 Dec 2015;
27. Human sensory neurons: membrane properties and sensitization by inflamatory mediators. PAIN 155 (2014) 1861-1870;
26. Size-Dependent Cellular Uptake and Expulsion of Single-Walled Carbon Nanotubes: Single Particle Tracking and a Generic Uptake Model for Nanoparticles. ACS Nano, 2009, 3 (1), pp 149–158;
25. Analysis of functional neuronal connectivity in the Drosophila brain. J Neurophysiol. 2012 Jul 15; 108(2): 684–696;
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