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Temperature Control > 1-Channel Temperature Controller

High stability Precision Temperature Controller TC-1-100s

A simplified  controller suitable for application where multiple temperature probes are not required: objective heaters, syringe heaters, heated glass plates, and other simple configurations (including custom heating elements). Can be used with Temperature controlled microscope stages, heated only. Easy to use and flexible self-adjusting controls for stable operation. Connection to an optional external probe (bath) is available. Stores two settings in its memory for different sample sizes/heating elements (different size objectives, for example), which can also be used to generate fast temperature steps.
  • No electrical noise
  • Built-in dual overheating protection, no temperature overshoot
  • No vibrations during imaging and recording - no internal fan
  • Standby mode
Most heating stages work as inline solution pre-heaters. Can be used with flow control and perfusion systems. Includes the connecting cable. Output is 12V/24V, which is suitable for most small microscope stage warmers, heating elements and objective heaters. Higher power outputs are available upon request (up to 35V). Sample publications.


Temperature sensor range:

room to to 150C


0.01C, required for sensitive applications: nano/piezo positioning, confocal imaging for example


self-adjusting; flexible, allow to stabilize temperature in different sample volumes and heating stage sizes; allow to regulate output from 0 to 96W - to prevent temperature overshoot and to provide overheating protection


STAGE sensor

External probe:

allows to monitor BATH/SAMPLE temperature (optional)


100-240VAC 150W



Click on catalog numbers below to purchase online.

Required accessories: heating stages.

Optional accessories: perfusion system, flow control.

Download PDF manual.

Download PDF catalog.

The picture below demonstrates high temperature stability provided by TC-1-100s controller. This is a temperature recording from TC-E35 35mm aperture heater for CSC chambers and Petri dishes. Most of the data points are between 0.01C deviation from 30C set level. The cursor is placed at 29.99C level. The data points were obtained every second.

Bioscience Tools
ph: 877-853-9755, fax: 866-533-7490




1-Channel Temperature Controller, high stability



1-Channel 150W high stability Temperature Controller, for high temperature applications



Miniature 0.87mm temperature Probe



Cable Assembly for TC-1-100S controller (included with the controller). A heating element can be attached to the cable connectors.

Sample publications:
24 Protocol to culture and image pancreatic ductal adenocarcinoma tumor slices to study T cell migration. STAR Protocols, Volume 4, Issue 1, 17 March 2023, 102135;
23 Exosome secretion kinetics are controlled by temperature. Biophysical J. Volume 122, Issue 7, 4 April 2023, Pages 1301-1314;
22 Optical sensing based on phase interrogation with a Youngs interference hologram using a digital micromirror device. Optics Express Vol. 32, Issue 3, pp. 3647-3659 (2024);
21 Stress accumulation by confined ice in a temperature gradient. PNAS, July 29, 2022;
20 Controlling Kinetic Pathways in Demixing Microgel-Micelle Mixtures. Langmuir, 39(3), 2023;
19 Investigating Spatiotemporal Kinetics, Dynamics, and Mechanism of Exosome Release. University of Denver Digital Commons, 2022;
18 In Vivo Wireless Brain Stimulation via Non-invasive and Targeted Delivery of Magnetoelectric Nanoparticles. Neurotherapeutics volume 18, pages20912106 (2021);
17 Optical measurement of microvascular oxygenation and blood flow responses in awake mouse cortex during functional activation. SAGE Jornal, 2022;
16 Addressing challenges in the removal of unbound dye from passively labelled extracellular vesicles. Nanoscale Adv., 2022, 4, 226-240;
15 Programming Directed Motion with DNAGrafted Particles. ACS Nano 2022, 16, 9195−9202;
14 A microfluidic optimal experimental design platform for forward design of cell-free genetic networks. Nature Communications, 13, 2022;
13 Ultrasound Mediated Cellular Deflection Results in Cellular Depolarization. Advanced Science, Volume 9, Issue2, January 14, 2022;
12 Baseline oxygen consumption decreases with cortical depth. PLOS Biology, October 27, 2022;
11 A compact microscope for voltage imaging. Journal of Optics, Volume 24, Number 5, 2022;
10 Noc Corrals Migration of FtsZ Protofilaments during Cytokinesis in Bacillus subtilis. mBio January/February 2021 Volume 12 Issue 1;
9 Controlling phase separation in microgel-polymeric micelle mixtures using variable quench rates. arXiv:2104.04022v1 8 Apr 2021;
8 Addressing challenges in the removal of unbound dye from passively labelled extracellular vesicles. Nanoscale Adv., 2022, 4, 226-240;
7 Soft crystal martensites: An in situ resonant soft x-ray scattering study of a liquid crystal martensitic transformation. Science Advances 27 Mar 2020;
6 The Min System Disassembles FtsZ Foci and Inhibits Polar Peptidoglycan Remodeling in Bacillus subtilis. mBio 2019;
5 Reversible temperature-controlled gelation in mixtures of pNIPAM microgels and non-ionic polymer surfactant. Soft Matter Issue 42, 2019;
4 Directed self-assembly of liquid crystalline blue-phases into ideal single-crystals. Nature communications 2041-1723 Jun 2017;
3 Intracellular temperature mapping with fluorescence-assisted photoacoustic-thermometry. Appl. Phys. Lett. 102, 193705 (2013);
2 Mesoscale martensitic transformation in single crystals of topological defects. PNAS September 5, 2017 11207;
1 Development of a Quantitative Recombinase Polymerase Amplification Assay with an Internal Positive Control. JOVE 3/30/2015, Issue 97;